[A11458] CAS 6553-96-4 | 2,4,6-Triisopropylbenzenesulfonyl chloride, 98%

CAS : 6553-96-4
UN# : UN3261
MDL : MFCD00007433
Hazard Class : 8
EINECS : 229-479-6
Packing Group : II

Other name :

Trisyl chloride

Chemical Properties

Formula : C15H23ClO2S
Formula weight : 302.87
Melting Point : 94-97°
Sensitivity : Moisture Sensitive. Store under Nitrogen. Ambient temperatures.
Form : Crystalline powder
Solubility : Soluble in chloroform.

Literature References

Hindered sulfonyl chlorides have found use as condensing agents for the formation of the phosphate link of oligonucleotides. For reviews, see: Angew. Chem. Int. Ed., 11, 451 (1972); Synthesis, 222 (1975); Chem. Rev., 77, 183 (1977). For reviews of oligonucleotide synthesis by the phosphotriester method, see: Heterocycles, 7, 1197 (1977); Tetrahedron, 34, 3143 (1978). For use as a condensing agent in the synthesis of H-phosphonate diesters, see: Nucleosides Nucleotides, 7, 23 (1988). More hindered in comparison with, e.g. Mesityl­ene-2-sulfonyl­ chloride, A11775, and so has less tendency to react with the free 5′-hydroxyl group of sugars: J. Am. Chem. Soc., 88, 829 (1966). For examples of the utility of the triisopropylbenzenesulfonyl group in the protection of OH groups, see: J. Am. Chem. Soc., 117, 5693, 5776 (1995): (first synthesis of a digitalis saponin and asymmetric synthesis of (-) and (+)-strychnine, respectively).

Notes

Incompatible with strong bases.Other References:Beilstein: 1218575UN#: UN3261

Grade Specifications

Grade Specifications

Hazard Statements : H314-H318Causes severe skin burns and eye damage.Causes serious eye damage.
Precautionary Statements : P260-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501aDo not breathe dust/fume/gas/mist/vapours/spray.IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.