[J62659] CAS 78415-72-2 | Milrinone, 98+% | Alfa
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Brand: Alfa Aesar
78415-72-2 | C12H9N3O | milrinone corotrope milrila corotrop
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Chemical Identifiers
CAS
78415-72-2
Molecular Weight (g/mol)
211.22
Synonym
milrinone corotrope milrila corotrop
SMILES
CC1=C(C=C(C#N)C(=O)N1)C1=CC=NC=C1
InChI Key
PZRHRDRVRGEVNW-UHFFFAOYSA-N
Molecular Formula
C12H9N3O
IUPAC Name
2-methyl-6-oxo-1,6-dihydro-[3,4′-bipyridine]-5-carbonitrile
Specifications
Appearance (Color)
Pale cream to cream
Residue on ignition
≤0.5%
Form
Powder or crystals or crystalline powder
Loss on Drying
≤1.0%
Assay from Supplier’s CofA
≥98.0%
설명
It is used (particularly intravenously, as the lactate) for the short-term management of severe heart failure. Milrinone inhibits the action of phosphodiesterase-3 preventing degradation of cAMP. The corresponding increase in cAMP levels leads to increased activation of protein kinase A. It is a selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
It is used (particularly intravenously, as the lactate) for the short-term management of severe heart failure. Milrinone inhibits the action of phosphodiesterase-3 preventing degradation of cAMP. The corresponding increase in cAMP levels leads to increased activation of protein kinase A. It is a selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity.
It is used (particularly intravenously, as the lactate) for the short-term management of severe heart failure. Milrinone inhibits the action of phosphodiesterase-3 preventing degradation of cAMP. The corresponding increase in cAMP levels leads to increased activation of protein kinase A. It is a selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity.
Solubility
Soluble in DMSO. Insoluble in water.
Notes
Store away from oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.
Other References:
Merck Index:14,6197UN Number:UN2811
GHS Hazard and Precautionary Statements
Hazard Statements:H301+H311+H331
GHS H StatementH300-H311-H331 Fatal if swallowed.Toxic in contact with skin.Toxic if inhaled.
Precautionary Statements:P261-P264b-P270-P271-P280-P301+P310-P302+P352-P304+P340-P311-P312-P330-P361-P363-P501c
Risk & Safety
TSCA:NoRTECS Number:DW1762000
경고:RUO – Research Use Only
CAS78415-72-2FORMULAC12H9N3OHAZARD CLASS6.1EINECS278-903-6MDLMFCD00133539PACKAGING GROUPIII
| Pakage | 100mg, 10MG, 50mg |
|---|---|
| brand | Alfa Aesar |
