[02195527-CF] CAS 738-70-5 | Trimethoprim | MP bio
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02195527-CF | CAS 738-70-5 | Trimethoprim | MPBIO
Key Features and Details
Trimethoprim
| SKU | 02195527-CF |
| Alternate Names | 2,4-Diamino-5-[3,4,5-trimethoxybenzyl]pyrimidine; 5-[(3,4,5-Trimethoxyphenyl) methyl]-2,4-pyrimidinediamine |
| Application Notes | Trimethoprim is primarily used as an antibacterial agent. It has dihydrofolate reductase inhibitor activity with selectivity for the prokaryote enzyme. It is used to treat urinary tract infections, mild acute prostatitis, recurrent cystitis, asymptomatic bacteriuria during pregnancy and respiratory tract infections. |
| Base Catalog Number | 195527 |
| Beilstein Registry Number | 625127 |
| Biochemical Physiological Actions | The combination of trimethoprim and sulfamethoxazole interferes with the cellular metabolism of folic acid in the bacterial cell by blocking the biosynthesis of nucleotides. Trimethoprim binds to dihydrofolate reductase and inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF). THF is an essential precursor in the thymidine synthesis pathway and interference with this pathway inhibits bacterial DNA synthesis. |
| CAS # | 738-70-5 |
| EC Number | 212-006-2 |
| Melting Point | 390 to 397° F (NTP, 1992) |
| Molecular Formula | C14H18N4O3 |
| Molecular Weight | 290.323 g/mol |
| Personal Protective Equipment | Eyeshields, Gloves, respirator filter |
| RTECS Number | UV8225000 |
| Solubility | less than 1 mg/mL at 75° F (NTP, 1992) |
| Usage Statement | Unless specified otherwise, MP Biomedical’s products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. |
