[02195690-CF] CAS 19545-26-7 | Wortmannin | MP bio
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[1s-(1a,6ba,9ab,11a,11bb)]-11-(Acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-7,9,a,11b-dimethyl-3-furo (4,3,2-de)indeno[4,5,-h]-2-benzopyran-3,6,9-trione; KY 12420 /
Wortmannin
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02195690-CF | CAS 19545-26-7 | Wortmannin | MP bio
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Wortmannin
| SKU | 02195690-CF |
| Alternate Names | 1s-(1a,6ba,9ab,11a,11bb) |-11-(Acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-7,9,a,11b-dimethyl-3-furo (4,3,2-de)indeno4,5,-h |-2-benzopyran-3,6,9-trione; KY 12420 |
| Application Notes | Wortmannin is a commonly used cell biology reagent that has been used previously in research to inhibit DNA repair, receptor-mediated endocytosis and cell proliferation. It inhibits fMLP induced PIP3 and superoxide anion production in guinea pig neutrophils. It blocks insulin metabolic effects in rat adipocytes without affecting the insulin receptor tyrosine kinase activity. |
| Base Catalog Number | 195690 |
| Beilstein Registry Number | 67676 |
| Biochemical Physiological Actions | Wortmannin is a potent and specific phosphatidylinositol 3-kinase (PI3-K) inhibitor. Inhibition of PI3-K/Akt signal transduction cascade enhances the apoptotic effects of radiation or serum withdrawal and blocks the antiapoptotic effect of cytokines. Inhibition of PI3-K by wortmannin also blocks many of the short-term metabolic effects induced by insulin receptor activation. |
| CAS # | 19545-26-7 |
| Format | Powder |
| Hazard Statements | H300-H310-H330 |
| Molecular Formula | C23H24O8 |
| Molecular Weight | 428.437 g/mol |
| Personal Protective Equipment | Eyeshields, Faceshields, full-face particle respirator, Gloves, respirator cartridge, respirator filter |
| RTECS Number | CB9641000 |
| Safety Symbol | GHS06 |
| Source | Penicillium wortmannii |
| Usage Statement | Unless specified otherwise, MP Biomedical’s products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. |
| brand | MP Bio |
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