[02101162-CF] Butylated hydroxyanisole | MP bio
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Brand: MP Bio
Butylated Hydroxytoluene
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02101162-CF | Butylated hydroxyanisole | MPBIO
Key Features and Details
Butylated Hydroxytoluene
| SKU | 02101162-CF |
| Alternate Names | 2,6-Di-tert-Butyl-p-Cresol; BHT; 2,6-Di-t-Butyl-4-MethylPhenol; Butylhydroxytoluene; DBPC; 2,6-Di-tert-butyl-4-methylphenol; 2,6-bis(1,1-Dimethylethyl)-4-methylphenol |
| Base Catalog Number | 101162 |
| Beilstein Registry Number | 1911640 |
| Biochemical Physiological Actions | Butylated hydroxytoluene (BHT) has been shown to inhibit lipid peroxidation. It causes lung injury and promotes tumors in mice, but this may be due to a metabolite of BHT, 6-tert-butyl-2-[2′-(2′-hydroxymethyl)-propyl]-4-methylphenol. Metabolites of BHT have also been reported to induce DNA strand breaks and internucleosomal DNA fragmentation (a characteristic of apoptosis) in cultured cells. In rats, a single intraperitoneal injection of BHT (60 mg/kg body mass) results in a significant increase in nuclear DNA methyl transferase activity in the liver, kidneys, heart, spleen, brain and lungs. Incubation of alveolar macrophages with BHT significantly reduced the level of TNF-α which may explain the mechanism by which this antioxidant reduces inflammation. Preincubation of aspirin-treated platelets with BHT inhibits the secretion, aggregation, and protein phosphorylation induced by protein kinase C activators. BHT was also found to inhibit the initiation of hepatocarcinogenesis by aflatoxin B1. |
| Boiling Point | 509° F at 760 mm Hg (NTP, 1992) |
| CAS # | 128-37-0 |
| Density | 1.048 at 68° F (NTP, 1992) |
| EC Number | 204-881-4 |
| Extinction Coefficient | EmM(278 nm)=1.75-1.83 (in methanol)(Lit.) |
| Flash Point | 260° F (NTP, 1992) |
| Format | Crystalline powder |
| Hazard Statements | H302-H315-H319-H411 |
| Melting Point | 156 to 160° F (NTP, 1992) |
| Molecular Formula | C15H24O |
| Molecular Weight | 220.356 g/mol |
| Personal Protective Equipment | Dust mask, Eyeshields, Gloves |
| RTECS Number | GO7875000 |
| Safety Symbol | GHS07, GHS09 |
| Solubility | less than 1 mg/mL at 68° F (NTP, 1992) |
| Usage Statement | Unless specified otherwise, MP Biomedical’s products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. |
| Vapor Density | 7.6 (Air = 1) |
| Vapor Pressure | 0.01 mm Hg (NIOSH, 2016) |
