[02154163-CF] CAS 9002-04-4 | Thrombin, high purity grade, ≥1500 NIH U/mg protein | MP bio
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02154163-CF | CAS 9002-04-4 | Thrombin, High Purity, ≥1500 NIH U/mg | MPBIO
Key Features and Details
- Serine protease that selectively cleaves Arg-Gly bonds in fibrinogen to form fibrin and fibrinopeptides A and B
- Thrombin is prepared from fresh bovine plasma by an ion exchange method
- Thrombin solution is clarified by centrifugation and filtration and then lyophilized
| SKU | 02154163-CF |
| Alternate Names | Factor IIa |
| Application Notes | α-Thrombin is a trypsin-like serine protease involved in a multitude of processes in the human body. Thrombin generation is the result of limited proteolysis of the vitamin K-dependent zymogen prothrombin. Thrombin is the last enzyme in the clotting cascade functioning to cleave fibrinogen to fibrin which forms the fibrin gel of a hemostatic plug or a pathologic thrombus. In addition, thrombin potentiates the procoagulant process by activating Factors V, VIII, XI and XIII. |
| Base Catalog Number | 154163 |
| Biochemical Physiological Actions | Serine protease that selectively cleaves Arg-Gly bonds in fibrinogen to form fibrin and fibrinopeptides A and B. |
| CAS # | 9002-04-4 |
| EC Number | 232-648-7 |
| Grade | High Purity |
| Hazard Statements | H315-H319-H334-H335 |
| RTECS Number | XO8950000 |
| Safety Symbol | GHS07, GHS08 |
| Source | Bovine |
| Specific Activity | ≥1500 NIH u/mg protein |
| Unit Definition | The unit defined by the U.S. standard and is approximately equal to the stated unitage. A U.S. unit is defined as the amount required to clot 1 mL of standardized fibrinogen solution in 15 seconds. Approximately 2 U.S. units are required to clot 1 ml of oxalated human plasma in the same period of time. U.S units = NIH units. |
| Usage Statement | Unless specified otherwise, MP Biomedical’s products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. |
