[02194157-CF] CAS 1264-72-8 | Colistin sulfate salt, ≥15,000 U/mg | MP bio
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02194157-CF | CAS 1264-72-8 | Colistin sulfate salt, ≥15,000 U/mg | MPBIO
Key Features and Details
- Mixture of cyclic polypeptides colistin A and B
- Effective against most Gram-negative bacilli
- Used as a polypeptide antibiotic.
| SKU | 02194157-CF |
| Alternate Names | Polymyxin E, Colistin sulphate salt |
| Application Notes | Colistin sulfate is used to permeabilize bacterial cell membranes and to study mannose-resistant haemagglutination and antibiotic resistance in certain organisms such as A. baumannii. It has been used to study hephrotoxicity in the rat kidney, and MICs, time-kill kinetics, and postantibiotic effect (PAE) against Pseudomonas aeruginosa. |
| Base Catalog Number | 194157 |
| Biochemical Physiological Actions | Mode of Action: Binds to lipids on the cell cytoplasmic membrane of Gram-negative bacteria and disrupts the cell wall integrity. Antimicrobial spectrum: Gram-negative bacteria. It is proposed that renal reabsorption of colistin may involve organic cation transporters and peptide transporters and that the process is sensitive to pH. |
| CAS # | 1264-72-8 |
| EC Number | 215-034-3 |
| Hazard Statements | H301 |
| Molecular Weight | 1253.527 g/mol |
| Personal Protective Equipment | Eyeshields, Faceshields, Gloves, respirator cartridges |
| RTECS Number | TR1500000 |
| Specific Activity | ≥15,000 u/mg |
| Usage Statement | Unless specified otherwise, MP Biomedical’s products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. |
