[02195262-CF] CAS 28822-58-4 | 3-Isobutyl-1-methyl xanthine | MP bio
... people are viewing this right now
02195262-CF | CAS 28822-58-4 | 3-Isobutyl-1-methyl xanthine | MPBIO
Key Features and Details
IBMX has been shown to be a potent, non-specific inhibitor of adenosine 3′,5′-cyclic monophosphate phosphodiesterase (cAMP PDE)4, significantly more effective than theophylline. Also inhibits cGMP phosphodiesterases. IBMX inhibits cyclic nucleotide PDE with subsequent inhibition of cyclic nucleotide hydrolysis, resulting in accumulation of cyclic AMP and guanosine 3′,5′-cyclic monophosphate.
| SKU | 02195262-CF |
| Alternate Names | IBMX; MIX; MeiBu-Xan; IBX; 1-Methyl-3-isobutylxanthine, 3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione, 3-Isobutyl-1-methyl-2,6(1H,3H)-purinedione |
| Application Notes | IBMX helps in inhibition of phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50 = 1.3 uM). Also inhibits ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. Inhibits the growth of carcinoma cells both in vivo and in vitro in mice. |
| Base Catalog Number | 195262 |
| Beilstein Registry Number | 247859 |
| Biochemical Physiological Actions | Non-specific inhibitor of cAMP and cGMP phosphodiesterases. The increase in cAMP level as a result of phosphodiesterase inhibition by IBMX activates PKA leading to decreased proliferation, increased differentiation, and induction of apoptosis. IBMX inhibits phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50: 1.3 µM). Also serves as an adenosine receptor antagonist. Shown to inhibit ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. Induces calcium release from intracellular stores in sensory neurons. |
| CAS # | 28822-58-4 |
| EC Number | 249-259-3 |
| Melting Point | 195 – 202 °C |
| Molecular Formula | C10H14N4O2 |
| Molecular Weight | 222.25 |
| Personal Protective Equipment | Dust mask , Eyeshields, Faceshields, Gloves |
| RTECS Number | ZD8500000 |
| Safety Symbol | GHS07 |
| Solubility | Soluble in Krebs-Henseleit bicarbonate buffer, ethanol (10 mg/mL or 25 mg/mL with sonication), DMSO (1 M with warming), or aqueous NaOH (pH 9.5); slightly soluble in water (0.3 mg/mL hot water). Solubility in 45% (w/v) aqueous 2-hydroxy-propyl-b-cyclodextrin is 3.2 mg/mL. |
| Usage Statement | Unless specified otherwise, MP Biomedical’s products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. |
