[114066102] CAS 703-95-7 | 5-FOA (5-fluoroorotic acid), 1 g | MP bio
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Brand: MP Bio
2,6-Dihydroxy-5-fluoropyrimidine-4-carboxylic acid; 5-Fluorouracil-4-carboxylic acid; 5-Fluoroorotate; Fluoroorotic Acid; FOA; 4-Pyrimidinecarboxylic Acid; 5-Fluoro-1,2,3,6-Tetrahydro-2,6-Dioxo-(9CI); 1,2,3,6-Tetrahydro-2,6-Dioxo-5-Fluoro-4-Pyrimidinecarboxylic Acid; 5-Fluoro-6-Carboxyuracil /
5-Fluoroorotic Acid monohydrate is a derivative of a pyrimidine precursor and is selectively toxic to yeast cells which synthesize orotidine-5’-phosphate decarboxylase.
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114066102 | CAS 703-95-7 | 5-FOA (5-fluoroorotic acid), 1 g | MP bio
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Key features and details
5-Fluoroorotic Acid monohydrate is a derivative of a pyrimidine precursor and is selectively toxic to yeast cells which synthesize orotidine-5’-phosphate decarboxylase.
| SKU | 114066102 |
| Alternate Names | 2,6-Dihydroxy-5-fluoropyrimidine-4-carboxylic acid; 5-Fluorouracil-4-carboxylic acid; 5-Fluoroorotate; Fluoroorotic Acid; FOA; 4-Pyrimidinecarboxylic Acid; 5-Fluoro-1,2,3,6-Tetrahydro-2,6-Dioxo-(9CI); 1,2,3,6-Tetrahydro-2,6-Dioxo-5-Fluoro-4-Pyrimidinecarboxylic Acid; 5-Fluoro-6-Carboxyuracil |
| Application Notes | 5-Fluoroorotic Acid monohydrate (FOA) is used as a selective agent in yeast molecular genetics. Curing yeast strains of plasmids, plasmid shuffling, allelic replacement, and two-hybrid screens are methods that can employ the use of 5-FOA. It is also used in the selection of Ura cells in a population of Ura+ cells; and in the selection of orotidine-5’-phosphate decarboxylase (OMPdecase) mutants of Saccharomyces cerevisiae. FOA (0.1 mg/mL) has been used in the positive selection for uracil auxotrophs of the sulfur-dependent thermophilic archaebacterium Sulfolobus acidocaldarius. It is a noncompetitive inhibitor of dihydroorotase. FOA (50% inhibition, 6 nM) was a selective inhibitor of malarial cells of Plasmodium falciparum in vitro and in vivo. FOA showed anti-tumor activity against transplanted tumors in rats and mice; a bacteriostatic effect in vitro against various microorganisms, particularly gram-negative bacteria; antimycotic activity against various types of mold. |
| Base Catalog Number | 4066102 |
| CAS # | 703-95-7 |
| EC Number | 211-876-0 |
| Format | Powder |
| Grade | Molecular Biology Certified™ |
| Media Type | Attachments Factors |
| Melting Point | 278 °C (dec.) (Lit.) |
| Molecular Formula | C5H3FN2O4·H2O |
| Molecular Weight | 174.09 (anhydrous) |
| Pack Size | 1 g |
| Personal Protective Equipment | Personal Protective Equipment Respiratory protection: Breathing apparatus only if aerosol or dust is formed. Hand protection: PVC or other plastic material gloves Skin and body protection: Usual safety precautions while handling the product will provide adequate protection against this potential effect. Eye protection: Safety glasses with side-shields Hygiene measures: Handle in accordance with good industrial hygiene and safety practice |
| Safety Symbol | GHS07 |
| Solubility | Soluble in 4 M NH4OH (50 mg/mL)(Sonication or heating may be needed), slightly soluble in water. |
| Typical Working Concentration | 1 mg/mL has been used as a selective agent in yeast molecular genetics |
| Usage Statement | Unless specified otherwise, MP Biomedical’s products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. |
| brand | MP Bio |
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