[A11727] CAS 3112-85-4 | Methyl phenyl sulfone, 98+%

CAS : 3112-85-4
MDL : MFCD00014741
EINECS : 221-476-8

Chemical Properties

Formula : C7H8O2S
Formula weight : 156.20
Melting Point : 85-88°
Sensitivity : Ambient temperatures.
Form : Crystalline powder
Solubility : Soluble in methanol, ethanol, benzene, and chloroform. Partly miscible in water.

Literature References

Factors governing the selective alkylation have been studied. Lithium bases favor dialkylation. For monoalkylation, a potassium base, e.g. KH in THF, should be used: J. Org. Chem., 55, 2234 (1990). Adds to aldehydes and ketones in the presence of base, e.g. n-BuLi, to give ß-hydroxy sulfones. Conversion of the OH to, e.g. to mesylate, and elimination/desulfurative reduction with sodium amalgam provides a 1-substitued or 1,1-disubstituted alkene by the Julia olefination reaction: Tetrahedron Lett., 4833 (1973); J. Chem. Soc., Perkin 1, 829 (1978). For reaction scheme, see Ethyl­ phenyl­ sulfone, A10710. The adducts with aldehydes can also be rearranged to give the dimethyl acetals of the homologous aldehydes: J. Chem. Soc., Perkin 1, 1646 (1978). Reaction with acyl halides gives ß-keto sulfones: J. Org. Chem., 53, 906 (1988).

Applications

Methyl phenyl sulfone, a versatile building block for the construction of chemicals with diverse functionalities

Grade Specifications

GHS Hazard and Precautionary Statements

Hazard Statements : H302Harmful if swallowed.
Precautionary Statements : P264-P270-P301+P312-P330-P501aWash thoroughly after handling.Do not eat, drink or smoke when using this product.IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.Rinse mouth.Dispose of contents/container in accordance with local/regional/national/international regulations.Other References:Beilstein: 1906914