[A13380] CAS 151-10-0 | 1,3-Dimethoxybenzene, 98%

CAS : 151-10-0
MDL : MFCD00008384
EINECS : 205-783-4

Other name :

Resorcinol dimethyl ether

Chemical Properties

Formula : C8H10O2
Formula weight : 138.17
Melting Point : -52°
Boiling Point : 217-218°
Flash point : 87°(188°F)
Density : 1.065
Refractive Index : 1.5250
Sensitivity : Ambient temperatures.
Form : Liquid
Solubility : Miscible with toluene.

Literature References

Is readily metallated at the 2-position by n-BuLi, giving a lithio-derivative which is doubly-stabilized by oxygen coordination. For reviews, see: Org. React., 8, 258 (1954); 26, 1 (1979). The 2-lithio-derivative undergoes silylation, and the resulting silyl derivative reacts with electrophiles to give various 2-substituted products. For examples, see: Tetrahedron, 49, 10843 (1993): Although direct dilithiation with n-BuLi/TMEDA was unsuccessful, a sequence involving monolithiation, silylation and further lithiation at the 4-position gave the 2,4-disilyl derivative in 47% yield: J. Org. Chem., 49, 4657 (1984). For a review of the use of organosilicon intermediates in unusual electrophilic substitutions, see: Synlett, 171 (1993).

Notes

Incompatible with strong oxidizing agents.Other References:Beilstein: 878582

Grade Specifications

Grade Specifications

Hazard Statements : H312-H227Harmful in contact with skin.Combustible liquid.
Precautionary Statements : P261-P280hAvoid breathing dust/fume/gas/mist/vapours/spray.Wear protective gloves/clothing.