[B20970] CAS 2916-68-9 | 2-(Trimethylsilyl)ethanol, 98+%

CAS : 2916-68-9
UN# : UN1987
MDL : MFCD00002825
Hazard Class : 3
EINECS : 220-844-5
Packing Group : III

Other name :

2-Hydroxyethyltrimethylsilane

Chemical Properties

Formula : (CH3)3SiCH2CH2OH
Formula weight : 118.25
Boiling Point : 71-72°/10mm
Flash point : 50°(122°F)
Density : 0.825
Refractive Index : 1.4250
Sensitivity : Ambient temperatures.
Form : Liquid
Solubility : Miscible with water.

Literature References

Carboxyl groups can be protected as 2-(trimethylsilyl)ethyl (TMSE) esters by carbodiimide coupling: Helv. Chim. Acta, 60, 2711 (1977); J. Org. Chem., 62, 93 (1997), from the acid chloride in pyridine: Helv. Chim. Acta, 60, 3039 (1977), or refluxing the acid in THF in the presence of TMS chloride: J. Am. Chem. Soc., 106, 3030 (1984). The TMSE protecting group is useful in peptide synthesis. Cleavage is readily effected with TBAF in DMF or DMSO: Helv. Chim. Acta, 60, 2711 (1977); Bioorg. Med. Chem. Lett., 3, 437 (1993).

Notes

Keep away from sources of ignition. Keep container tightly closed in a dry and well-ventilated place.Other References:Beilstein: 1732034UN#: UN1987

Grade Specifications

Grade Specifications

Hazard Statements : H226-H315-H319-H335Flammable liquid and vapour.Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.
Precautionary Statements : P210-P241-P303+P361+P353-P305+P351+P338-P405-P501aKeep away from heat/sparks/open flames/hot surfaces. – No smoking.Use explosion-proof electrical/ventilating/lighting/ equipment.IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.