[J62579] CAS 1229-29-4 | Doxepin hydrochloride | Alfa
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Brand: Alfa Aesar
1229-29-4 | C19H22ClNO | hydrogen doxepin chloride
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Chemical Identifiers
CAS
1229-29-4
Molecular Weight (g/mol)
315.84
Synonym
hydrogen doxepin chloride
SMILES
[H+].[Cl-].CN(C)CCC=C1/C2=CC=CC=C2COC2=CC=CC=C12
InChI Key
MHNSPTUQQIYJOT-SJDTYFKWSA-N
Molecular Formula
C19H22ClNO
IUPAC Name
hydrogen dimethyl({3-[(2E)-9-oxatricyclo[9.4.0.0³,⁸]pentadeca-1(15),3,5,7,11,13-hexaen-2-ylidene]propyl})amine chloride
Specifications
Assay (unspecified)
98.0% min.
Assay (unspecified)
Z-isomer: 13-18.5%
Loss on Drying
0.5% max.
Melting Point
185-191?C
Sulfated Ash
0.2% max.
설명
It is a highly potent H1 histamine receptor antagonist (Kd = 310 pM) and tricyclic antidepressant that inhibits the reuptake of serotonin and norepinephrine and acts as an antagonist at histamine, serotonin, adrenergic, and muscarinic receptors with Ki values in the nanomolar range. Also binds to the H4 histamine receptor (pKi = 6.79). Used clinically to treat anxiety and depression.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Solubility
Soluble in water (100 mM), chloroform (1:2), alcohol (1:1), methanol, and DMSO.
Soluble in water (100 mM), chloroform (1:2), alcohol (1:1), methanol, and DMSO.
Notes
Store away from oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.
Other References:
Merck Index:14,3435UN Number:UN2811
GHS Hazard and Precautionary Statements
Hazard Statements:H301-H361
GHS H StatementH301-H361 Toxic if swallowed.Suspected of damaging fertility or the unborn child.
Precautionary Statements:P201-P202-P264b-P270-P281-P301+P310-P308+P313-P330-P501c
Risk & Safety
TSCA:NoRTECS Number:HQ4375000
경고:RUO – Research Use Only
CAS1229-29-4FORMULAC19H22ClNOHAZARD CLASS6.1EINECS214-966-8MDLMFCD00079135PACKAGING GROUPIII
| Pakage | 1g, 25g, 5g |
|---|---|
| brand | Alfa Aesar |
