[L09968] CAS 7226-23-5 | 1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone, 98%

CAS : 7226-23-5
MDL : MFCD00006550
EINECS : 230-625-6

Other name :

N,N’-DimethylpropyleneureaDMPU

Chemical Properties

Formula : C6H12N2O
Formula weight : 128.18
Melting Point : -23°
Boiling Point : 246-247°
Flash point : 120°(248°F)
Density : 1.060
Refractive Index : 1.4890
Sensitivity : Hygroscopic. Ambient temperatures.
Form : Liquid
Solubility : Miscible with water.

Literature References

Dipolar aprotic solvent recommended as a replacement for the carcinogenic hexamethylphosphoric triamide (HMPA) in many reactions: Helv. Chim. Acta, 65, 385 (1982). DMPU is non-mutagenic: Chimia, 39, 148 (1985). It is more useful than the lower homologue 1,3-Dimethyl-2-imidazolidinone, A16001 (mp 8oC) for low-temperature reactions. Can be used as a general replacement for HMPA in organolithium reactions: J. Am. Chem. Soc., 107, 719 (1985). Has been found to be comparable to HMPA in promoting reductive coupling reactions with SmI2: J. Am. Chem. Soc., 110, 5064 (1988); J. Chem. Soc., Chem. Commun., 1775 (1992), and also in other reductions with the same reagent: J. Org. Chem., 58, 5008 (1993).

Notes

Hygroscopic. Moisture sensitive. Incompatible with strong oxidizing agents.Other References:Beilstein: 110562

Grade Specifications

Grade Specifications

Hazard Statements : H301-H318-H361Toxic if swallowed.Causes serious eye damage.Suspected of damaging fertility or the unborn child.
Precautionary Statements : P280-P301+P310-P305+P351+P338-P321-P405-P501aWear protective gloves/protective clothing/eye protection/face protection.IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.Specific treatment (see label).Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.