[L11911] CAS 68957-94-8 | 1-Propylphosphonic acid cyclic anhydride, 50+% soln. in ethyl acetate

CAS : 68957-94-8
UN# : UN2924
MDL : MFCD00006583
Hazard Class : 3
EINECS : 422-210-5
Packing Group : II

Other name :

1-Propanephosphonic acid cyclic anhydrideT3P

Chemical Properties

Formula : C9H21O6P3
Formula weight : 318.19
Boiling Point : 77°
Flash point : -3°(26°F)
Density : 1.080
Refractive Index : 1.4190
Sensitivity : Moisture Sensitive. Ambient temperatures.
Form : Liquid
Solubility : Miscible with dichloromethane, dimethyl formamide, dioxane, terahydrofuran, polar and aprotic organic solvents.

Literature References

T3P is a registered trademark of Clariant Group. Condensation agent in formation of amide and ester linkages. In peptide synthesis, gives high yields, low racemization, and minimization of side reactions without the need for additives, as well as easily removable (water soluble) by-products: Angew. Chem. Int. Ed., 19, 133 (1980). Also reported for formation of a Weinreb amide in high yield from the acid and N,O-dimethylhydroxylamine: Angew. Chem. Int. Ed., 36, 1191 (1997). Activating agent for epoxidation of alkenes, giving cis-stereoselectivity in reactions with allylic alcohols: Tetrahedron Lett., 35, 8125 (1994). For a brief reviews of the reagent, see: Synlett, 1369 (2000); 1328 (2007). For peptide reagents, see Appendix 6.

Notes

Moisture sensitive. Incompatible withstrong oxidizing agents.Other References:Beilstein: 5079255UN#: UN2924

Grade Specifications

Grade Specifications

Hazard Statements : H225-H314-H336Highly flammable liquid and vapour.Causes severe skin burns and eye damage.May cause drowsiness or dizziness.
Precautionary Statements : P210-P241-P303+P361+P353-P305+P351+P338-P405-P501aKeep away from heat/sparks/open flames/hot surfaces. – No smoking.Use explosion-proof electrical/ventilating/lighting/ equipment.IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.